Pharmacological Interventions in Oxysterol Metabolism: Side Effects and Biochemical Consequences

HR  EN   

Project acronym: OXYMED

Project number: 581-UNIOS-82 

Principal investigator: Prof. Marija Heffer, MD, PhD, Faculty of Medicine Osijek
Funding source: European Union – NextGeneration EU
Project duration: 1 October 2025. to 30 September 2029.
Budget: 108.550,00 EUR

Project summary:

Numerous pharmacological interventions, as well as conditions involving deficiencies of coenzymes participating in antioxidative enzymatic reactions, lead to elevated levels of oxysterols – lipid signaling molecules. Oxysterols are markers of oxidative damage and contribute to the development of atherosclerosis, neurodegenerative processes, and immune system disorders. By recognizing their imbalance, adverse side effects can be prevented, treatment can be accelerated, and healthcare costs reduced. This study will examine oxysterol levels and associated metabolic changes induced by a selected set of drugs (antipsychotics, agonists of target receptors, and corticosteroids) using an animal model or clinical studies (women of middle and premenopausal age and children aged 12–18 years). In addition, the study will investigate the association between oxysterols and B-complex deficiency in the neonatal period, with the aim of determining threshold values for supplementation interventions to prevent severe neurological damage. The purpose of the obtained findings is to improve clinical practice and raise awareness among professionals and the public about the importance of monitoring medication side effects. The project goals are aligned with the program indicators and strategic objectives of the program-based financing.